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Updated: Jul 3, 2026

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
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Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

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在肉瘤诊断和治疗中下一代测序的指导方针:共识审查

César Serrano1,2, Sebastian Bauer3,4, Jean-Yves Blay5

  • 1Sarcoma Translational Research Group, Vall d'Hebron Institute of Oncology, Barcelona, Spain.

JAMA oncology
|October 16, 2025
PubMed
概括

下一代测序 (NGS) 由于稀有性和异质性,不建议对所有肉瘤患者进行常规测序. 专家审查对于解释NGS结果在肉瘤诊断和治疗中至关重要.

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Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...