在对干眼治疗的随机对照试验中评估的结果:系统性审查
Yuhui Wu1, Michael X Lin2,3, Daniel Shaughnessy4,5
1Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD.
Cornea
|October 16, 2025
概括
这一系统性审查确定了干眼病 (DED) 临床试验中常见的结果. 不一致的测量工具凸显了对DED研究标准化核心成果集的需求.
科学领域:
- 眼科医生 眼科 眼科
- 临床试验方法论 临床试验方法论
背景情况:
- 干眼病 (DED) 影响全球数百万人,需要标准化的研究实践.
- 目前对DED治疗的随机对照试验 (RCT) 缺乏结果测量的一致性.
研究的目的:
- 启动为DED制定一个核心成果集.
- 系统地审查DEDRCT中报告的所有结果.
主要方法:
- 搜索了PubMed和Embase在2016年至2024年之间发表的DED RCT.
- 两位独立审查员对研究进行了选,并提取了结果领域和测量工具.
- 完善了用于数据分类的DED结果分类法.
主要成果:
- 包括来自6477个独特记录的300个RCT.
- 最常见的结果:眼膜稳定性 (90.6%),眼部症状 (84.3%),角膜染色 (75.7%) 和眼产生 (66.0%).
- 在研究中使用的测量仪器中发现了显著的变化.
结论:
- 结果指标和工具的广泛变化强调了对DED核心结果集的关键需求.
- 接下来的步骤涉及对核心开发的确定结果的优先考虑.
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