病中的新型分子生物标志物:弥合早期检测和临床实施之间的差距
Bhavana Bagdaram Choudhary1, Bhupendra Puri1, Anil Bhanudas Gaikwad1
1Department of Pharmacy, Birla Institute of Technology and Science Pilani, Pilani Campus, Vidya Vihar, Pilani, Rajasthan 333031, India.
The Journal of pharmacy and pharmacology
|October 16, 2025
概括
新的生物标志物显示出早期病检测和个性化治疗的前景. 这些进展旨在通过及时干预和监测功能来改善患者的治疗结果.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 生物标志物发现发现
- 翻译医学是一种翻译医学.
背景情况:
- 脏疾病影响全球超过8.5亿人,对健康构成重大挑战.
- 目前的生物标志物 (血清肌素,BUN,蛋白尿) 缺乏早期检测的敏感性和特异性.
- 现有的FDA批准的生物标志物由于炎症,感染或疾病阶段的影响而存在局限性.
研究的目的:
- 审查新兴的生物标志物用于早期检测和监测各种病.
- 涵盖急性损伤,慢性病,糖尿病病,多囊病,狼性炎和细胞癌.
- 提供关于新型诊断和预后标志物的最新概述.
主要方法:
- 对过去十年发表的研究进行了全面的文献综述.
- 专注于基于尿液和血液的生物标志物.
- 分析反映关键病理过程的标记物:炎症,管道损伤,纤维化和免疫激活.
主要成果:
- 确定了一些有前途的生物标志物,包括聚光素,奥尔法托美丁4,激素A,利斯塔丁,USP18,加列克-3,费图因-A,塞斯特林-2,波多卡利辛,科佩,抗C1q,p-cresol糖胺,血清CD206,长非编码RNA (lncRNAs) 和微RNA (miRNAs).
结论:
- 新兴的生物标志物为提升病的早期诊断提供了潜力.
- 这些标记物可能有助于个性化治疗,并改善患者的治疗结果.
- 将其纳入临床实践可以弥合早期发现和对病的有效干预之间的差距.
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