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Updated: Jan 15, 2026

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

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P-Rex1限制了GPCRs的激素诱导内部化,而不依赖于其Rac-GEF活动

Martin J Baker1, Elizabeth Hampson2, Priota Islam2

  • 1Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge, UK; Cell Signalling Group, Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester, UK.

Cell reports
|October 16, 2025
PubMed
概括

关氨酸核酸交换因子P-Rex1调节G蛋白合受体 (GPCR) 信号传递和贩运. 通过与Grk2相互作用,P-Rex1限制了GPCR内部化,在血膜上保持活跃的GPCR.

关键词:
科普:分子生物学 分子生物学G蛋白结合受体的受体是G蛋白结合受体的受体.环保环境基金 (GEF) 提供在GPCR中,GPCR是指GPCR.格鲁吉亚克朗2格鲁吉亚克朗2在PREX1中使用PREX1在PREX2中使用PREX2.激进主义诱导的内部化.关氨酸核化物交换因子走私和贩运的人口贩运

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