液状硬化和甲状腺疾病之间的关联:系统性审查和元分析
Po-Chien Wu1, I-Hsin Huang1, Cheng-Chen Tai2
1Department of Dermatology, Chang Gung Memorial Hospital, Linkou Main Branch, Guishan Dist, Taoyuan, Taiwan.
Indian journal of dermatology, venereology and leprology
|October 16, 2025
概括
状硬化 (LS) 与甲状腺疾病,特别是自身免疫性甲状腺炎和哈希莫托甲状腺炎有显著的关联. 这一发现表明需要提高对LS患者甲状腺疾病的认识和查.
科学领域:
- 皮肤病学 皮肤病学
- 内分泌学 在内分泌学.
- 自体免疫学 自体免疫学
背景情况:
- 状硬化 (LS) 是一种慢性炎症性皮肤疾病,可疑是自身免疫源.
- 以前的研究表明LS与自身免疫性疾病之间存在联系,但与甲状腺疾病的关联仍然存在争议.
研究的目的:
- 系统地审查和元分析状样硬化和各种甲状腺疾病之间的关联.
主要方法:
- 通过使用CENTRAL,MEDLINE和Embase的数据进行了病例控制研究的系统审查和元分析.
- 包括9项涉及超过177,000名LS患者和220万对照者的研究.
- 偏差风险使用纽卡斯尔-太华尺度进行评估.
主要成果:
- 在LS和甲状腺疾病之间发现了显著的关联,包括甲状腺炎 (OR 2.07) 和自身免疫甲状腺炎/哈希莫托甲状腺炎 (OR 2.97).
- 调整后的分析表明,在LS患者中,甲状腺功能低下症 (aOR 1.91) 和自身免疫甲状腺炎/哈希莫托甲状腺炎 (aOR 2.88) 的几率增加.
- 包含的研究质量很高,得分为7或更高.
结论:
- 在状硬化和甲状腺疾病之间存在显著的关联,特别是自身免疫性甲状腺炎和哈希莫托甲状腺炎.
- 临床医生应监测LS患者的甲状腺相关症状,并考虑早期内分泌评估.
- 需要对不同种群和标准化定义进行进一步的研究.
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