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在ORCHARD-EPR中 Delirium 患病率,诊断不确定性和结果:与潜在的参考队列相对验证

Emily Louise Boucher¹, Jasmine Ming Gan¹, Nicola Georgia Lovett²

¹University of Oxford, Wolfson Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, Wolfson Building, Headington, Oxford, United Kingdom.

|October 16, 2025

概括

使用电子病历 (EPR) 的老年住院患者的 Delirium 查发现了显著的患病率,结果与之前的队列相似. 这突出了EPR的重要意义.

科学领域:

老年医学老年医学
神经科学是一个神经科学.
临床信息学临床信息学

背景情况:

痴呆症在老年医院患者中经常被诊断不足.
电子患者记录 (EPR) 系统可以促进妄想查.
之前的研究依赖于前性队列来评估妄想.

研究的目的:

为了确定老年住院患者 Delirium 的患病率,特征和结果.
使用强制性的EPR基查与之前的潜在队列进行比较.
评估牛津认知并发症,虚弱和衰老研究数据库 (ORCHARD-EPR) 系统的有效性.

主要方法:

分析了70岁以上急性通用医学患者的两个队列:ORCHARD-EPR (2017-2019) 和潜在队列 (2010-2018).
花园-EPR使用混乱评估方法和缩短精神测试 (AMT) 进行妄想选.
潜在队列中痴呆症诊断遵循DSM-IV标准;住院死亡率几率比率根据共变量进行调整.

主要成果:

在ORCHARD-EPR (n=18,614) 中,17%的人患有确定的妄想,11%的人患有不确定的妄想;每组中39%的人同时患有痴呆症.
在潜在的队列中 (n=731),38%的人患有妄想症,35%的人患有痴呆症.
虚弱,低AMT得分,感染和低血症在某些和不确定的妄想中更常见.
在某些妄想症,不确定的妄想症和潜在的队列中,过度死亡率是可比的.

结论:

痴呆症的诊断不确定性是常见的,特别是没有关键风险因素.
在EPR队列中, Delirium的总体患病率低于前队列.
尽管患病率有差异,但痴呆的同时发生率和患者的结果相似,验证了EPR查和ORCHARD-EPR的研究潜力.

关键词:

妄想妄想妄想妄想妄想痴呆症痴呆症是一种痴呆症.诊断的不确定性诊断的不确定性电子健康记录是电子健康记录.老年人年长的人.参考标准是指参考标准的参考标准.

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