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Updated: Jan 15, 2026

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蝙蝠沙贝科病毒WIV1-CoV携带一种适应性突变,改变了尖峰动态并增强了ACE2结合

Alexandra L Tse1, Gorka Lasso1, Jacob Berrigan1

  • 1Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, New York, United States of America.

PLoS pathogens
|October 16, 2025
PubMed
概括

像SHC014-CoV和WIV1-CoV这样的蝙蝠沙贝科病毒显示其尖端蛋白中的遗传适应,增强了ACE2结合和细胞进入. 这些变化可能会促进动物传播的蔓延,为SARS-CoV-2的出现提供了替代途径.

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