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Updated: Jan 15, 2026

Solid-phase Synthesis of [4.4] Spirocyclic Oximes
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PPh3 - 促进硫-迈克尔添加驱动循环:一种不同的途径,以获取螺旋铁原衍生物

Jyoti Chauhan1, Jyoti Sikarwar1, Rama Krishna Peddinti1

  • 1Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand 247 667, India.

The Journal of organic chemistry
|October 16, 2025
PubMed
概括

一种新的方法合成复杂的spirothiochromanone衍生品,使用trifenylphosphine催化剂和一种新的硫替代品. 这种高效的过程简化了有价值的含硫螺旋环化合物的产生.

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Preparation and Reactions of Sulfides

Sulfides are the sulfur analog of ethers, just as thiols are the sulfur analog of alcohol. Like ethers, sulfides also consist of two hydrocarbon groups bonded to the central sulfur atom. Depending upon the type of groups present, sulfides can be symmetrical or asymmetrical. Symmetrical sulfides can be prepared via an SN2 reaction between 2 equivalents of an alkyl halide and one equivalent of sodium sulfide.
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Robinson annulation is a base-catalyzed reaction for the synthesis of 2-cyclohexenone derivatives from 1,3-dicarbonyl donors (such as cyclic diketones, β-ketoesters, or β-diketones) and α,β-unsaturated carbonyl acceptors. Named after Sir Robert Robinson, who discovered it, this reaction yields a six-membered ring with three new C–C bonds (two σ bonds and one π bond).
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