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Updated: Jan 15, 2026

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通过新设计揭示了T细胞受体特异性景观

Gian Marco Visani1, Michael N Pun2, Anastasia A Minervina3

  • 1Paul G. Allen School of Computer Science and Engineering, University of Washington, Seattle, WA 98195.

Proceedings of the National Academy of Sciences of the United States of America
|October 16, 2025
PubMed
概括

这项研究引入了一种计算方法,用于预测MHC分子上的T细胞受体 (TCR) 与的相互作用,并设计免疫性. 该方法准确预测TCR-pMHC结合和T细胞活性,有助于疫苗和工程T细胞治疗设计.

关键词:
T细胞pMHC识别的方法T细胞的特异性T细胞的特异性一个新的体设计.一个等价神经网络.基于结构的蛋白质机器学习

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