在美国处方艾滋病毒暴露后预防的人群趋势,2015-2023年
John N Le1, Weiming Zhu1, Ya-Lin A Huang1
1Division of HIV Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
概括
艾滋病毒暴露后预防 (PEP) 的使用正在增加,基于比克特格拉维尔的疗法显著增加. 这一趋势突显出越来越多的意识和艾滋病毒预防策略的潜在转变.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 暴露后预防 (PEP) 对于在潜在暴露后预防艾滋病毒感染至关重要.
- 分析PEP使用和治疗方案选择的趋势对于优化HIV预防策略至关重要.
研究的目的:
- 描述使用HIV PEP的个体的特征.
- 分析国家对PEP方案的趋势,包括CDC推的和非标签的基于比克特格拉维尔的选择.
主要方法:
- 使用了IQVIA真实世界数据-纵向处方数据库 (2015-2023年).
- 包括年龄在16岁以上的处方ARV PEP的个人,不包括已有艾滋病毒或正在接受治疗的人.
- 通过临床医生审查确认了可能的PEP处方,并分析了用户人口统计和供应持续时间.
主要成果:
- 孕产妇预防药物处方的数量显著增加,从2015年的20,618人增加到2023年的44934人.
- 基于比克特格拉维尔的PEP使用量从2018年的4.1%升至2023年的16.8%.
- 在2023年,53.8%的PEP使用者是男性,39.8%的年龄在25-34岁之间,而88.4%的使用者接受了28-30天的完整供应.
结论:
- 每年PEP使用量呈上升趋势,这表明意识增加和更广泛的艾滋病毒预防工作.
- 基于比克特格拉维尔的PEP使用量的增加表明,由于有利的剂量和耐受性,处方做法可能会发生转变.
- 结果可以为未来的推提供信息,以最佳选择PEP药物.
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