替代的TMA-93版本在早期阿尔茨海默氏病中表现出可比的性能和区分精度
José Enrique Arriola-Infante1,2, Ernesto García-Roldán3, David García-Solís4
1Department of Neurology, Torrecárdenas University Hospital, Almería, Spain.
Journal of Alzheimer's disease : JAD
|October 16, 2025
概括
新版本的TMA-93记忆测试显示了与原始测试对早期阿尔茨海默病 (AD) 诊断的同等性能. 这一发现支持在纵向研究中使用TMA-93版本B.
科学领域:
- 神经学 神经学
- 认知神经科学 认知神经科学
- 生物标志物研究 生物标志物研究
背景情况:
- TMA-93是用于早期阿尔茨海默病 (AD) 诊断的经过验证的简要记忆测试.
- 对于原来的TMA-93.3,已有确定的规范数据和基于生物标志物的切断值存在.
研究的目的:
- 开发一个替代版本 (版本B) 的TMA-93.3.
- 将TMA-93版本B的诊断性能与原始版本A进行比较.
主要方法:
- 预期招募无认知障碍健康对照 (HC) 和轻度认知障碍或痴呆症患者.
- 将TMA-93版本A和B给HC和具有AD生物标志物的患者.
- 对HC组之间的总分数进行比较,对患者的测试-再测试可靠性 (ICC) 的评估,以及对生物标志物确认的AD的歧视性表现的评估.
主要成果:
- 接受A或B版本的HC组之间的测试分数没有显著差异.
- 在包括AD患者在内的患者中,对TMA-93的良好测试-重新测试可靠性 (ICC).
- 曲线下的可比面积 (AUC) 用于区分A (0.95) 和B (0.90) 版本的AD.
结论:
- 新的TMA-93版本B与原始版本A相当.
- TMA-93版本B适用于用于早期AD诊断的纵向评估.
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