通过alexithymia,与青少年使用药物相关的与工作记忆相关的大脑激活和关闭
Benjelene D Sutherland1, Lauren D Hill-Bowen2, Elisa M Trucco3
1Department of Psychology, Florida International University, Miami, FL, United States.
Developmental cognitive neuroscience
|October 16, 2025
概括
难以识别情绪 (alexithymia) 可能将青少年工作记忆 (WM) 功能与电子烟使用联系起来. 关键WM区域的下脑活动与较高的alexithymia相关,预测了以后的尼古丁使用.
科学领域:
- 神经科学是一个神经科学.
- 青少年心理学 青少年心理学
- 药物使用研究研究 药物使用研究
背景情况:
- 青少年物质使用 (SU) 仍然是一个重大的公共卫生问题.
- 工作记忆 (WM) 和相关的大脑活动与SU病因有关.
- 亚历克西西米亚的特点是情绪处理困难,可能是WM和SU的桥梁.
研究的目的:
- 调查alexithymia作为与WM相关的大脑活动和青少年SU之间的调解者.
- 为了检查WM任务执行,大脑激活,alexithymia和电子烟,大麻和酒精使用之间的关系.
主要方法:
- 在137名青少年的长度研究中,在n-back WM任务中使用fMRI.
- 序列调解模型评估了侧面前额皮层 (lPFC) /上椎 (STG) 活动,WM表现,alexithymia和SU之间的联系.
- 随着时间的推移,模型的重点是电子烟,大麻和酒精使用.
主要成果:
- 较少的lPFC与WM相关的激活与较高的alexithymia相关,预测电子烟使用增加.
- 较少的STG禁用与较高的alexithymia相关,也预测了电子烟使用量的增加.
- 对于大麻或酒精的使用,没有发现显著的间接影响.
结论:
- 亚历克西西米亚是WM能力和青少年电子烟使用之间的机制联系.
- 在WM区域中大脑功能的改变可能使青少年易患情绪失调和尼古丁使用.
- 结果表明,针对青少年SU的干预措施可能是潜在的目标.
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