PAK6驱动瘤微环境重塑与淋巴结结缩的鼻癌:对远程转移和生存的影响

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Siqi Xu¹, Wenqian Xu¹, Xiuhua Li²

¹Department of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, China.

International immunopharmacology

|October 16, 2025

概括

淋巴结亡 (LNN) 是鼻癌 (NPC) 的一个不良预后指标. 高表达的p21激活激酶6 (PAK6) 与糟糕的结果相关,并驱动NPC进展,表明PAK6作为治疗点.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学是一个遗传学.

背景情况:

鼻癌 (NPC) 经常表现为淋巴结转移.
淋巴结亡 (LNN) 与NPC患者的不良临床结果有关.
了解LNN及其分子驱动因素的影响对于改善NPC预后至关重要.

研究的目的:

为了调查淋巴结亡 (LNN) 在鼻癌 (NPC) 的预后意义.
确定LNN和NPC进展之间的关联背后的分子机制.
评估p21激活激酶6 (PAK6) 作为NPC中的潜在治疗标.

主要方法:

在147个NPC样本上进行了RNA测序,以确定LNN和非LNN组之间的差异表达基因 (DEG).
统变逻辑回归和LASSO回归被用于识别转移相关基因并构建预后风险模型.
功能性测试 (例如,殖民地形成,CCK-8,伤口愈合) 和分子分析 (RT-qPCR,IHC) 用于验证和评估PAK6.6的作用.

主要成果:

在LNN和非LNNNNPC样本中确定了258个DEG.
一个预后风险模型将p21激活激酶6 (PAK6) 确定为关键基因;高的PAK6表达与预后不佳相关 (p <0.05).
PAK6倒置抑制了NPC细胞的增殖,迁移和殖民地形成,并且与PI3K-Akt通路和CD8+ T细胞有关.

结论:

淋巴结亡 (LNN) 是鼻癌 (NPC) 的一个显著的预后因素.
21激活激酶6 (PAK6) 在NPC进展中起着关键作用,与生存率差相关.
帕克6代表了一种潜在的治疗标,用于提高NPC患者的治疗结果.

关键词:

免疫微环境是一个微环境.淋巴结结核死症淋巴结结核死症鼻癌是指鼻癌.在PAK6中,PAK6是PAK6.

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