悲伤特异性语音噪声障碍和精神分裂症的次区域左岛体积减小,有听觉语言幻觉
Bingyan Gong1, Qiuhong Li2, Shenglin She3
1Department of Psychological and Cognitive Sciences, Tsinghua University, 100084, China.
Asian journal of psychiatry
|October 16, 2025
概括
患有精神分裂症的个体经历听觉语言幻觉 (AVHs),表现出情绪语音识别受损和左侧胰岛灰质减少. 左侧胰岛的结构异常可能是这些缺陷的基础,提供了潜在的生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 神经成像是一种神经成像.
背景情况:
- 听觉语言幻觉 (AVH) 是精神分裂症的一个核心症状.
- 情绪语音噪音识别 (ESR) 缺陷在精神分裂症中很常见.
- 岛屿在情绪处理中的作用及其在精神分裂症中的结构完整性具有重要意义.
研究的目的:
- 在精神分裂症患者中调查左岛区域体积,ESR和AVH之间的关联.
- 确定AVH和相关认知缺陷的潜在神经解剖相关物.
主要方法:
- 结构性MRI用于对58名精神分裂症患者的左侧胰岛体积分析.
- 根据PANSS P3得分,患者被分为AVH和非AVH组.
- 所有参与者都接受了情绪语音噪音识别 (ESR) 任务.
主要成果:
- 与非AVH患者相比,AVH患者在五个左侧岛屿次区域的悲伤和减少灰质的ESR受损.
- 这些差异在控制认知症状和其他临床变量后减弱.
- 在正常化后,AVH患者在左腹部和背部的农岛子区域的体积仍然较小.
- 左半岛体积,特别是在背部的细粒体和细粒体区域,与AVH严重程度和ESR表现相关.
结论:
- 在特定的左侧岛屿子区域的结构异常与精神分裂症的情感语言处理缺陷有关.
- 这些发现突出了潜在的神经解剖学生物标志物和AVHs的治疗点.
- 进一步的研究应该考虑AVH的终身病史,以获得更强大的发现.
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