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相关概念视频

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

14.7K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Overview
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Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
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Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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T Cell Types and Functions01:24

T Cell Types and Functions

2.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

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The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
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相关实验视频

Updated: Jan 14, 2026

Generation of Orthotopic Pancreatic Tumors and Ex vivo Characterization of Tumor-Infiltrating T Cell Cytotoxicity
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Generation of Orthotopic Pancreatic Tumors and Ex vivo Characterization of Tumor-Infiltrating T Cell Cytotoxicity

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营养分配燃料 T 细胞介导免疫

Joseph Longo1, McLane J Watson1, Kelsey S Williams2

  • 1Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.

Cell metabolism
|October 16, 2025
PubMed
概括
此摘要是机器生成的。

T细胞激活依赖于代谢重编程,利用糖解和氧化酸化. 战略性营养成分分配为最佳的T细胞增殖和效应器功能提供燃料,修订了经典模型.

关键词:
在T细胞,T细胞.适应性免疫是一种适应性免疫.效应器的功能是效应器的功能.葡萄糖 葡萄糖 葡萄糖 是 一种免疫代谢的免疫代谢.营养物质的分配分配.

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Generation of Human Alloantigen-specific T Cells from Peripheral Blood
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相关实验视频

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Generation of Orthotopic Pancreatic Tumors and Ex vivo Characterization of Tumor-Infiltrating T Cell Cytotoxicity
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Real-time Monitoring of Mitochondrial Respiration in Cytokine-differentiated Human Primary T Cells
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Generation of Human Alloantigen-specific T Cells from Peripheral Blood
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Generation of Human Alloantigen-specific T Cells from Peripheral Blood

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科学领域:

  • 免疫学 免疫学 免疫学
  • 细胞的新陈代谢

背景情况:

  • T细胞激活与代谢重编程有关.
  • 经典模型侧重于葡萄糖驱动的有氧糖解 (华堡效应) 后T细胞受体 (TCR) 刺激.
  • 最近的发现表明,这个模型过于简单.

研究的目的:

  • 总结一下T细胞代谢的最新进展.
  • 提出T细胞代谢重编程的修订模型.
  • 突出营养可用性在T细胞功能中的作用.

主要方法:

  • 关于T细胞代谢的最新研究的综述.
  • 对T细胞中营养利用的分析.
  • 在体内和体外对T细胞代谢的研究.

主要成果:

  • 激活的T细胞同时利用糖解和氧化酸化 (OXPHOS).
  • 不同的营养来源被分配给不同的生物合成和生物能量目的.
  • 生理营养物质的可用性会影响T细胞增殖和效应因子功能的葡萄糖分配.

结论:

  • 一个修订后的模型认为,效应T细胞代谢涉及营养的战略分配.
  • 这种战略分配对于最佳的T细胞介导免疫是至关重要的.
  • 了解T细胞代谢是提高免疫反应的关键.