在巴西圣保罗的献血者中进行寨卡病毒流行后监测2016-2020年
Suzete Cleusa Ferreira1,2, José Eduardo Levi3, Anna Shoko Nishiya1,2
1Departamento de Segurança Transfusional, Fundação Pro Sangue Hemocentro de São Paulo, Divisão de Pesquisa, São Paulo, SP, Brazil.
Transfusion medicine (Oxford, England)
|October 16, 2025
概括
在巴西的一次献血中检测到寨卡病毒 (ZIKV) RNA,证实了其罕见但在流行病后持续存在. 对献血的持续监测对于早期发现潜在的ZIKV复苏至关重要.
科学领域:
- 病毒学 病毒学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 寨卡病毒 (ZIKV) 的传播主要是通过埃及蚊子 (Aedes aegypti) 传播,有记录的输血传播病例.
- 2015年巴西的ZIKV流行病突出了严重的并发症,包括孕妇胎儿小头症.
研究的目的:
- 评估寨卡病毒 (ZIKV) 在流行病后 (2016-2020年) 期间从健康个人捐献血液中的持久性.
主要方法:
- 在109,296个献血者样本中,使用血池的核酸测试 (NAT) 对ZIKVRNA进行查.
- 之前的HBV,HCV和HIV常规NAT也在这些样本上进行.
主要成果:
- 在2016年5月的一份捐赠样本中检测到ZIKVRNA (流行率0.0009%),通过桑格测序证实.
- 遗传学分析确定检测到的ZIKVRNA属于亚洲类,这是一种与2015年巴西流行病和小头病例相关的血统.
- 阳性捐赠者在最初捐赠一个月后显示血清转化.
结论:
- 在捐献血液中检测到ZIKV RNA证实了其罕见但持续存在的情况.
- 定期监测献血的病毒从过去的爆发可以帮助检测初始复苏,防止未来的流行病.
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