呼出的一氧化碳表明经过牙周治疗后持续的牙下硬化症
Sophie Koehlen1, Inga Harks1, Johannes Matern1
1Department of Periodontology and Operative Dentistry, Münster University Hospital, Münster, Germany.
Journal of clinical periodontology
|October 16, 2025
概括
呼出的一氧化碳 (CO) 可能表明经过牙周治疗后吸烟者持续的口腔失生症. 较高的二氧化碳水平与特定的细菌群相关,有助于监测治疗结果.
科学领域:
- 牙周病学 牙周病学
- 微生物组分析
- 生物标志物发现发现
背景情况:
- 牙周炎是一种常见的口腔炎症疾病.
- 下微生物群落在牙周炎中发挥着关键作用.
- 呼出的一氧化碳 (CO) 是吸烟的已知生物标志物.
研究的目的:
- 为了确定呼出的一氧化碳 (CO) 水平是否与下多微生物群相关.
- 为了研究这种关系之前和之后的非手术性牙周治疗.
- 评估CO作为牙周炎患者,特别是吸烟者的监测工具的有用性.
主要方法:
- 对163名患有牙周炎的成年人进行了随访.
- 呼出的CO和下斑块样本 (16S rRNA基因测序) 在治疗前和治疗后的2,14,26个月收集.
- 采用了针对共变量调整的专题模型和回归分析.
主要成果:
- 吸烟者表现出更高的二氧化碳水平和治疗后显著下降.
- 治疗前的CO并没有与失生症有关,但治疗后,较高的CO与它正相关.
- 在吸烟者中,增加的呼出CO2与特定的Fusobacterium和Prevotella主导的集群有关.
结论:
- 呼出的CO显示了在吸烟者中经过牙周治疗后监测持续性失生症的潜力.
- CO可能有助于识别特定的无氧化物主导的下社区.
- 自我报告的吸烟状态比单独的CO更强烈地预测了失生症.
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