相关实验视频
Updated: Jan 14, 2026
06:33
Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis
Published on: June 9, 2018
8.1K
双粉样性粉症:对111名患者的临床病理学和蛋白质学分析
Joanna C Dalland1, Surendra Dasari2, Jason D Theis1
1Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Human pathology
|October 16, 2025
概括
识别双粉样类型对于有效治疗至关重要. 这项研究分析了111名患有两种粉样蛋白类型的患者,发现AL加ATTR粉样蛋白最常见,特别是在心脏病例中.
科学领域:
- 心血管病理学心血管病理学
- 蛋白质组学是指蛋白质组学.
- 医学诊断 医学诊断 医学诊断
背景情况:
- 双粉样性粉症,即在一个病人身上存在两种不同的粉样类型,并不常见.
- 准确识别所有粉样类型至关重要,因为治疗方法根据前体蛋白质有很大差异.
研究的目的:
- 为了研究诊断为双粉样性粉症的患者的临床病理学和蛋白质学特征.
- 突出全面的粉样类型对患者管理的重要性.
主要方法:
- 通过液体染色学-并联质谱法 (LC-MS/MS) 类型化的51,309个粉样物的回顾性分析.
- 确定了111名患有双粉样类型的患者.
- 对人口统计,蛋白质组和临床数据的审查.
主要成果:
- 在111名患者 (83%是男性,中位数年龄为78岁) 中发现了双重氨基粉症.
- 在50%的患者中观察到心脏参与.
- 最常见的组合是免疫球蛋白轻链 (AL) 氨基粉症加 transthyretin (ATTR) 氨基粉症 (62%),特别是在心脏病例 (68%).
- 双粉样类型发生在相同或不同的解剖区内.
结论:
- 在所有情况下,全面的粉样蛋白类型化是必不可少的,利用形态学审查,并在临床发现异常时考虑双重类型.
- 从第二个解剖部位进行活检可能是必要的,以确定第二种粉样蛋白类型.
- 准确诊断双粉样性粉症指导适当的治疗策略.
更多相关视频
09:00Biochemical Purification and Proteomic Characterization of Amyloid Fibril Cores from the Brain
Published on: April 28, 2022
3.7K
10:51Consensus Brain-derived Protein, Extraction Protocol for the Study of Human and Murine Brain Proteome Using Both 2D-DIGE and Mini 2DE Immunoblotting
Published on: April 10, 2014
16.7K
相关概念视频
03:03Amyloid Fibrils
6.3K
6.3K
03:03Amyloid Fibrils
11.6K
Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
11.6K
01:27Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
458
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
458