用于制备,表征和低血糖效应的小豆沙波宁微囊,封装有改性小豆蛋白质
Liyun Deng1, Tao Chai2, Liang Li2
1Department of Endocrinology, Ya'an People's Hospital, Ya'an City, Sichuan Province, 625000, China.
International journal of biological macromolecules
|October 16, 2025
概括
微封装增强了小肥素的作用.
科学领域:
- 食品科学与技术 食品科学与技术
- 营养保健品 营养保健品
- 生物技术是生物技术.
背景情况:
- 小沙素具有低血糖特性,但具有较差的食感性和生物可用性.
- 这些限制阻碍了它们在功能性食品和治疗应用中的使用.
- 微封装为克服这些挑战提供了一个解决方案.
研究的目的:
- 使用改性豆蛋白和阿拉伯开发豆素微囊 (CSM).
- 评估CSM的物理化学特性,释放动力学和稳定性.
- 评估CSMs在糖尿病小鼠中的体内低血糖疗效.
主要方法:
- 复杂的化被用来准备CSMs.
- 分析了封装效率,药物加载量,颗粒大小和释放概况.
- 扫描电子显微镜 (SEM) 评估了微囊结构.
- 评估了热稳定性和体内低血糖活性.
主要成果:
- CSM实现了高封装效率 (76.84%) 和药物负载 (100.42 mg/g).
- 微囊在模拟的消化液中表现出持续释放和增强的热稳定性.
- 在体内研究表明,在糖尿病小鼠中,CSM的降糖效果优于免费的小豆素.
结论:
- 微封装有效地提高了小香的生物可用性和稳定性.
- CSM显示出显著的潜力来增强低血糖活动.
- 这项技术为在功能性食品中增加小肥素的应用开辟了道路.
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