用光热触发的双层水凝含有含有黄素的普卢兰衍生物,用于控制药物输送和伤口愈合
Punnida Nonsuwan1, Preeyaporn Plaimee Phiboonchaiyanan2, Verisa Chowjarean2
1Thammasat University Research Unit in Smart Materials and Innovative Technology for Pharmaceutical Applications (SMIT-Pharm), Faculty of Pharmacy, Thammasat University, Pathumthani, 12120, Thailand; Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand; Siriraj Center of Research Excellence in Theranostic Nanomedicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand.
International journal of biological macromolecules
|October 16, 2025
概括
这项研究开发了一种新的双层水凝,用于使用近红外 (NIR) 光控制黄素释放. 水凝通过促进细胞迁移和证明生物相容性来增强伤口愈合.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 药物输送系统 药物输送系统
背景情况:
- 先进的伤口愈合材料对于改善治疗结果至关重要.
- 需要有控制的药物释放系统来改善伤口护理.
- 黄素具有治疗潜力,但需要有效的输送策略.
研究的目的:
- 开发一种新型的双层水凝,用于控制黄素释放.
- 利用近红外 (NIR) 辐射作为药物释放的外部刺激.
- 评估水凝系统在促进伤口愈合方面的有效性.
主要方法:
- 制造一个双层水凝,其中含有黄素的底层 (Pul-βCD-MA/PEGDA) 和光热的顶层 (Pul-MA/多多巴胺).
- 描述水凝形态,机械特性和黄素释放动力学.
- 在体外评估伤口关闭使用细胞迁移测定与人类皮肤纤维细胞 (HDFs).
主要成果:
- NIR照射引发了顶层的温度升高,促进了可控的黄素释放 (33%在NIR照射下与15%没有NIR照射下).
- 与非辐射对照组相比,NIR刺激的水凝在体外显著增强了伤口关闭.
- 水凝系统与HDFs表现出极好的生物相容性,没有可检测的细胞毒性.
结论:
- 开发的双层水凝使黄素能够提供外部刺激响应的黄素.
- 从水凝中释放NIR触发的药物有助于有效的伤口愈合.
- 该系统代表了先进的伤口护理和可控药物输送应用程序的有希望的平台.
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