尿道甜味剂和糖与儿童肥胖相关:SWEET项目
Xinyi Cai1, Elske Brouwer-Brolsma1, Gerben de Gier1
1Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands.
The Journal of nutrition
|October 16, 2025
概括
尿中糖和糖与儿童肥胖指标有积极的关联,而果糖和葡萄糖等糖与肥胖指标有相反的关联. 生物标志物有助于澄清这些复杂的饮食模式.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 营养科学 营养科学
- 生物标志物研究 生物标志物研究
背景情况:
- 低卡路里和无卡路里甜味剂 (LNCS) 和糖对肥胖的影响受到争论,自我报告的饮食数据限制.
- 客观的饮食摄入量评估对于了解儿童肥胖症中的甜味剂和糖的作用至关重要.
研究的目的:
- 调查荷兰儿童和青少年尿液中LNCS和糖的度与体重指数 (BMI) 和腰与身高比 (WHtR) z-分数之间的关系.
- 在肥胖研究中利用客观生物标志物测量来克服自我报告的饮食摄入量的局限性.
主要方法:
- 来自生命线队伍的500名荷兰儿童和青少年 (8-17岁) 的尿样分析.
- 使用超压液体染色学-双重质谱法测量尿液中LNCS和糖度.
- 多变量线性回归模型根据年龄,性别,屏幕时间和水果/蔬菜摄入量进行调整,以评估与BMI和WHtRz-score的关联.
主要成果:
- 尿液中糖和糖的度与更高的BMI和WHtRz-score积极相关.
- 尿液中的总糖,果糖和葡萄糖度与BMI和WHtRz-score呈反向关联.
- 没有发现BMI/WHtRz-score与尿糖,LNCS总量,乙硫,环酸盐或醇之间有显著的关联.
结论:
- 尿中糖和糖与儿科人口的一般和腹部肥胖指标有积极联系.
- 尿中的糖 (总糖,葡萄糖,果糖) 和肥胖指标之间的反向关联表明基于体重状况的不同饮食模式.
- 生物标志物分析提供客观见解,克服饮食错误报告问题,了解与儿科肥胖相关的甜味剂和糖消费.
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