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营养补充剂和化品配方:对新兴过敏原的审查
Raymond Z Ezzat1, Thomas Stirrat1, Emily Nichols2
1From the Georgetown University School of Medicine, Washington, DC, USA.
Dermatitis : contact, atopic, occupational, drug
|October 16, 2025
概括
过敏性接触性皮肤炎 (ACD) 越来越多地与补充剂和化品有关. 新兴的过敏原,如维生素衍生物和草本提取物,需要更好的监管和诊断工具.
科学领域:
- 皮肤病学 皮肤病学
- 毒理学 毒理学 毒理学
- 监管科学 监管科学
背景情况:
- 营养补充剂和局部配方经常与过敏接触性皮肤炎 (ACD) 有关.
- 这些产品中ACD缺乏认可源于不一致的监管,有限的供应商意识,以及假设天然产品是安全的错误信念.
- 补充剂和化品中新出现的过敏原对公众健康构成越来越大的关注.
研究的目的:
- 在食补充剂和化品中识别新型过敏原.
- 描述与这些产品相关的过敏接触性皮肤炎反应.
- 突出诊断和调节补充剂和化品诱导的ACD的挑战.
主要方法:
- 进行了主要生物医学数据库 (PubMed,Embase,MEDLINE,Web of Science,CENTRAL) 的系统审查.
- 评估了报告与食补充剂和局部配方相关的ACD的研究.
- 确定了关键的敏感因子和反应模式.
主要成果:
- 发现的关键过敏原包括维生素衍生物 (多科菲罗尔,植物,甲酸),草本提取物 (银杏,黄,圣约翰草) 和抗氧化剂 (阿尔法-酸,白醇).
- 反应范围从局部性皮肤炎到全身性影响,通过贴片测试证实.
- 挑战包括未列出的成分,污染物和与氧化相关的过敏性使诊断复杂化.
结论:
- 由于补充剂和化品导致ACD的发病率越来越高,因此需要改进诊断方法,例如标准化贴片检测.
- 加强监管监督至关重要,包括强制性不良反应报告,市场前过敏原测试和敏感剂和植物成分的明确标签.
- 解决关于"天然"产品安全的误解对于公众健康意识至关重要.
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