良性性发性定位的功能性连接性改变:来自大脑休息状态网络的见解
Ke Yang1, Yutao Wang1, Li Jia1
1From the Department of Medical Imaging (K.Y., Y.W., L.J., X.Q., J.M., M.Z., Y.W), Department of Otolaryngology (J.X., Y.Y.), and Department of Respiratory and Critical Care Medicine (D.L.), the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
良性发性位置性 (BPPV) 涉及改变的大脑网络连接. 小脑网络 (CN) 显示连接性增加,可能成为BPPV治疗的神经成像点.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 良性发性位置性 (BPPV) 是最常见的外周.
- BPPV是由进入半圆形通道的脱离的耳引起的.
- 以前的研究表明,BPPV涉及多个大脑区域,但网络贡献仍然不清楚.
研究的目的:
- 研究BPPV患者大脑网络中的静止状态功能连接 (FC) 差异.
- 为BPPV的中央机制提供证据.
- 探索改变的FC和前庭功能之间的相关性.
主要方法:
- 与68名BPPV患者和60名健康对照进行的横截面研究.
- 独立组件分析 (ICA) 用于检测内部和网络之间的FC.
- 改变了连接的区域被用作整个大脑FC分析的种子.
主要成果:
- 在BPPV患者的听觉,小脑 (CN),执行控制和突出网络 (SN) 中发现了增加的网络内部FC.
- 在听觉,基底,默认模式 (DMN) 和SN中观察到改变的网络间FC.
- 在CN连接性和的强度之间存在正相关性.
结论:
- 在皮层和皮层下区域,BPPV表现出明显的内部和网络间连接性变化.
- 这些变化与前庭脑小区功能障碍有关.
- 小脑网络 (CN) 连接性可能是BPPV干预的神经成像目标.
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