在建筑环境中的表面上通过脉冲,275nm发光二极管和远紫外线源的辐射使SARS-CoV-2的无活化挑战
Lukas Oudejans1, Katherine Ratliff1, William Richter2
1Center for Environmental Solutions and Emergency Response, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, United States.
Environmental science & technology
|October 16, 2025
概括
紫外线-C (UVC) 设备显示出在表面上禁用SARS-CoV-2的潜力. 然而,在多孔材料和干燥的液滴上,疗效降低,这给现实应用带来了挑战.
科学领域:
- 微生物学 微生物学
- 环境健康 环境健康
- 辐射物理 辐射物理
背景情况:
- 随着COVID-19的爆发,人们越来越需要有效的表面消毒方法.
- 紫外线-C (UVC) 辐射正在被探索,因为它有可能使空气和表面结合的病原体如SARS-CoV-2无活化.
- 了解各种表面和条件上的UVC功效对于公共卫生应用至关重要.
研究的目的:
- 评估不同紫外线辐射发射装置在常见建筑环境表面上禁用SARS-CoV-2的有效性.
- 为了比较脉冲,275nmLED和222nm远紫外线光技术的性能.
- 评估表面多孔度,滴水湿度和注射剂类型对UVC失活效能的影响.
主要方法:
- 实验室使用三个UVC设备进行实验:脉冲的,275nm的LED和222nm的远UVC.
- 在组织培养基或模拟唾液中用SARS-CoV-2注射表面.
- 在湿和干滴条件下对硬无孔和多孔材料进行测试.
- 不同类型的注射剂的UVC吸收测量.
主要成果:
- 与多孔表面相比,UVC辐射在硬无孔表面上显示出显著的SARS-CoV-2无活化.
- 湿滴的效率高于干滴的效率.
- 无菌类对无活化的影响较小,尽管吸收在介质之间有所不同.
- 在更现实的干燥条件下观察到效率降低.
结论:
- 虽然UVC设备在SARS-CoV-2无活化方面表现有前途,但它们的有效性受表面类型和滴滴状态的影响.
- 从实验室环境过渡到现实世界条件 (干燥滴) 对有效的表面消毒提出了重大挑战.
- 需要进一步的研究来优化UVC的实施,以可靠地减少建筑环境中的风险.
相关概念视频
Physical Methods for Controlling Microbial Growth: Radiation and Filtration
991
Radiation and filtration are essential tools for microbial control, targeting microorganisms through distinct mechanisms. Radiation eliminates microbes by damaging their DNA, either killing them or inhibiting their growth. Based on wavelength, radiation is classified into two types: nonionizing and ionizing radiation.Non-ionizing radiation, such as UV radiation (200–400 nm), is absorbed by DNA, causing defects that effectively disinfect surfaces, air, and water, including safety cabinets.
991
Cleaning, Sterilization, and Disinfection
9.6K
Cleaning, disinfection, and sterilization are the methods that help to break the infection chain and prevent disease.
Cleaning
The cleaning process usually involves using water with detergents or enzymatic cleaner and removing foreign material from objects and surfaces, including organic material such as body fluids or inorganic material like soil. Cleaning is performed before high-level disinfection and sterilization because foreign materials on the cover of the devices interfere with process...
Cleaning
The cleaning process usually involves using water with detergents or enzymatic cleaner and removing foreign material from objects and surfaces, including organic material such as body fluids or inorganic material like soil. Cleaning is performed before high-level disinfection and sterilization because foreign materials on the cover of the devices interfere with process...
9.6K
Methods of Sterilization I: Physical Methods
23.4K
As used in a healthcare facility, sterilization destroys all microorganisms through physical or chemical methods. The physical method includes steam, dry heat, boiling water, and radiation.
Steam sterilization uses non-toxic, low-cost moist heat in the form of saturated steam under pressure, which is fast, microbicidal, and sporicidal, and quickly warms and penetrates fabrics. Autoclaves, or steam sterilizers, expose each item to direct steam contact for a predetermined time at the necessary...
Steam sterilization uses non-toxic, low-cost moist heat in the form of saturated steam under pressure, which is fast, microbicidal, and sporicidal, and quickly warms and penetrates fabrics. Autoclaves, or steam sterilizers, expose each item to direct steam contact for a predetermined time at the necessary...
23.4K
Chemical Agents for Microbial Control
754
Chemicals play important roles in controlling microbial growth by targeting microbial structures and functions as sanitizers, antiseptics, disinfectants, and sterilants.Alcohols are commonly used sanitizers, effectively disrupting lipid membranes, which compromises cell integrity. They are also used as antiseptics and disinfectants due to their rapid action and versatility.Phenols and their derivatives phenolics , known for denaturing proteins and disrupting cell membranes, are particularly...
754
Methods of Sterilization II: Chemical Methods
8.8K
In healthcare, the chemical method of sterilization uses chemical sterilants to treat surgical instruments and medical supplies to help prevent the transmission of infectious pathogens to patients. Due to heat sensitivity, most medical supplies and equipment should not be exposed to high temperatures. These parts include rubber, plastic, glass, and other similar elements.
Using chemical sterilization rather than heat to clean out equipment is recommended. It eradicates and removes all bacteria,...
Using chemical sterilization rather than heat to clean out equipment is recommended. It eradicates and removes all bacteria,...
8.8K
Mutations
42.7K
Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
42.7K


