在雄激素不敏感综合征中查淋巴腺恶性瘤:系统性审查
Najva Mazhari1, Andrew Freedman1, Caroline Marshall2
1Departments of Urology and Pediatrics, Cedars Sinai Medical Center, Los Angeles, CA, USA.
Journal of pediatric urology
|October 16, 2025
概括
在雄激素不敏感综合征 (AIS) 中缺少恶性查的标准化查. 目前的方法,通常是以专家为基础的,在检测早期瘤方面存在局限性,需要患者对淋巴结留风险的知情同意.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
背景情况:
- 淋巴切除术在历史上是雄激素不敏感综合征 (AIS) 的标准,因为存在恶性瘤问题.
- 由于内源性激素产生的好处和低的青春期前瘤风险,这种做法受到争议.
- 关于AIS患者长期恶性瘤风险的不确定性仍然存在.
研究的目的:
- 在AIS中审查现有的淋巴腺恶性查方案.
- 评估支持当前查策略有效性的证据.
- 确定理想的查方法,以早期检测前恶性/恶性变化.
主要方法:
- 按照PRISMA-P指南进行系统审查.
- 在多个数据库 (PubMed,Scopus等) 进行了搜索. 对于AIS,性腺瘤和查的研究.
- 分析了查方式,频率,敏感性,特异性和协议有效性的数据.
主要成果:
- 28项研究符合纳入标准;大多数建议是基于专家意见的.
- 经常引用的方法包括活检和超声波,但协议有很大的差异.
- 查有效性的证据有限;成像显示检测前恶性病变的局限性.
结论:
- 没有针对AIS相关恶性瘤的标准化查策略.
- 目前的查方法缺乏可靠的临床证据,并且主要基于专家的共识.
- 保持性腺的患者需要咨询风险,因为目前的查方案没有足够的证据支持.
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