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开发脂质作为具有低微分子宽谱抗orthoflaviviral活性的orthoflavivirin抑制剂

Lorenzo Cavina1, Anna Alocén Portillo1, Mike P A Balmer1

  • 1Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.

Journal of medicinal chemistry
|October 16, 2025
PubMed
概括

新型脂可以作为抗病毒疗法,对抗登革热,西尼罗河和寨卡等黄病毒病毒. 化合物73在小鼠中表现出强大的抗病毒活性和有利的药理动力学,这表明它具有治疗潜力.

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