饮食成分调节慢性病患者的肠道微生物群和相关生物标志物
Suwasin Udomkarnjananun1,2, Natthaya Chuaypen3, Kamonchanok Metta1
1Division of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, 1873 Rama 4 road, Pathumwan, Bangkok, 10330, Thailand.
Scientific reports
|October 16, 2025
概括
慢性病 (CKD) 患者表现出改变的肠道细菌,增加的三甲基胺-N-氧化物 (TMAO) 和炎症. 低蛋白,高纤维饮食可以通过促进有益细菌来改善CKD的肠道健康.
科学领域:
- 微生物学 微生物学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 营养科学 营养科学
背景情况:
- 肠道微生物群在慢性病 (CKD) 的进展中起着至关重要的作用.
- 饮食模式显著影响肠道微生物群组成和相关代谢物.
研究的目的:
- 调查肠道微生物群概况,血三甲基胺-N-氧化物 (TMAO) 和慢性病患者的炎症标志物之间的关联.
- 根据饮食模式来比较这些关联:低蛋白,高纤维 (LP-HF) 与高蛋白,低纤维 (HP-LF).
主要方法:
- 一项涉及135名CKD患者和19名健康对照者的横截面研究.
- 使用16S核糖体RNA测序分析便肠道微生物组合.
- 测量了血TMAO和细胞因子水平 (IL-18,MCP-1).
主要成果:
- 与对照组相比,CKD患者表现出明显的肠道微生物群变化,短链脂肪酸 (SCFA) 生产细菌减少.
- 慢性结核病患者的血TMAO和细胞因子水平显著升高.
- LP-HF饮食与更大的SCFA产生细菌丰富性有关,而HP-LF饮食丰富的蛋白质分解细菌 (例如,Klebsiella) 和更高的TMAO,IL-18和MCP-1水平.
结论:
- 慢性结核病的特征是显著的肠道失调和系统性炎症增加.
- 富含纤维,低蛋白质的饮食可以减轻肠道失调症和CKD患者的相关并发症.
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