在自闭症谱系障碍中异常形态发展的扩散轨迹
Yu Feng1,2, Weixing Zhao1,2, Youyi Li1,2
1The Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, PR China.
Communications biology
|October 16, 2025
概括
自闭症谱系障碍 (ASD) 在青春期显示出大脑灰质体积 (GMV) 的发育转变,从过度生长转向延迟成熟. 功能性大脑网络影响这些非典型的神经发育变化.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 自闭症研究 自闭症研究
背景情况:
- 了解自闭症谱系障碍 (ASD) 中的大脑发育是关键.
- 功能网络在调节ASD发育过程中大脑形态变化的作用尚不清楚.
研究的目的:
- 研究功能性大脑网络如何影响ASD个体大脑形态的发育变化.
- 分析灰色物质体积 (GMV) 和功能连接 (FC) 与ASD的神经发育轨迹相关.
主要方法:
- 使用ABIDE数据,分析了301名患有自闭症的个体和375名典型发育对照 (TDCs) 的GMV和FC,年龄为8-18岁.
- 采用滑窗方法和Kullback-Leibler分歧来量化跨年龄组的GMV偏差 (DEV).
- 利用网络扩散建模 (NDM) 来预测发育变化和评估神经发育上的网络约束.
主要成果:
- 观察到GMV分歧的发育转变:与TDC相比,ASD参与者在青春期早期的积极偏差在青春期晚期转变为负差.
- 在上角,环状回环,胰岛和上叶中发现了显著的GMV偏差.
- NDM证实,在早期阶段的非典型大脑区域DEV预测了随后的阶段,受到网络架构的限制.
结论:
- 在整个青春期,自闭症表现出一种动态的发育转变,从灰质过度生长到延迟成熟.
- 内在的功能性大脑网络在限制ASD非典型解剖发展方面发挥着至关重要的作用.
更多相关视频
09:13Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder
Published on: April 22, 2015
17.0K
10:11Portable Intermodal Preferential Looking IPL: Investigating Language Comprehension in Typically Developing Toddlers and Young Children with Autism
Published on: December 14, 2012
19.0K
相关概念视频
01:19Autism Spectrum Disorder
962
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
962
01:18Cognitive Development During Adolescence
491
During adolescence, individuals experience significant cognitive development that enhances their understanding of others' emotions and thoughts, known as cognitive empathy. This period is marked by an increased ability to adapt to others' perspectives and a more nuanced understanding of others' mental states, a skill that is foundational for social problem-solving and conflict avoidance. The development of cognitive empathy relies heavily on the theory of mind — the...
491
01:26Modeling in Therapy
378
Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
378
01:30Oppositional Defiant Disorder
621
A persistent pattern of angry or irritable mood, defiant behavior, or vindictiveness characterizes Oppositional Defiant Disorder (ODD). Symptoms must occur over at least six months, involve interactions with individuals beyond siblings, and meet specific diagnostic criteria to be clinically significant. The disorder affects emotional regulation, social interactions, and behavior, often manifesting early in life and influencing long-term development and functioning.
Diagnostic Criteria and...
Diagnostic Criteria and...
621
02:07Tumor Progression
7.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.2K
01:27Introduction to Developmental Psychology
1.4K
Developmental psychology explores the changes and continuities in human abilities throughout life, encompassing physical, cognitive, linguistic, and social dimensions. Human development is not restricted to growth, but includes aspects of decline, particularly in physical abilities as individuals age. Developmental psychologists seek to understand how people change as they age and how their mental and social skills evolve.Developmental MilestonesA key concept in developmental psychology is...
1.4K