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Updated: Jan 14, 2026

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在活细胞中诱导凝聚环挤出轨迹的表征

Ruiqi Han1,2, Yike Huang3, Michelle J Robers3

  • 1Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, the Netherlands. r.han@nju.edu.cn.

Nature genetics
|October 16, 2025
PubMed
概括

凝聚素 (SMC1-SMC3-RAD21) 挤出DNA环来组织染色体. 一个新的工具,TArgeted Cohesin Loader (TACL),可以控制循环挤出的激活,揭示复杂的网络及其对基因转录和染色质结构的影响.

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