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性特异性肠道细菌社区结构:对艾滋病毒感染者的脆弱风险的影响

Aline Zaparte¹, John W Lammons², Christopher M Taylor²

¹Department of Medicine, Section On Critical Care Medicine & Allergy, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, 70112, USA.

|October 16, 2025

概括

艾滋病毒 (PWH) 感染者的虚弱与肠道细菌有关,有明显的基于性别的差异. 某些肠道微生物预测脆弱性,建议针对PWH进行有针对性的干预.

科学领域:

微生物组研究微生物组研究
老年学是一门学科.
免疫学免疫学免疫学

背景情况:

虚弱是与衰老相关的重大健康问题,特别在艾滋病毒感染者 (PWH) 中流行.
肠道微生物组组成越来越被认为是影响脆弱性的因素,特别是在老年人中.
PWH有较高的早期发病脆弱性风险,需要对促成因素进行调查.

研究的目的:

为了研究肠道微生物组组成和艾滋病毒感染者 (PWH) 的脆弱性之间的关系.
探索肠道微生物组与PWH之间的脆弱性相关的基于性别的差异.
为了确定特定的细菌种群和社区状态,预测这个群体的脆弱性.

主要方法:

对来自268名参与新奥尔良艾滋病毒 (NOAH) 研究的268名参与者的便样本中的16S rRNA基因测序的分析.
使用表型脆弱指数 (PFI) 和58项赤字指数 (DI-58) 评估脆弱性.
测量细胞因子水平,病毒载荷和T细胞计数;识别社区状态类型 (CST).

主要成果:

14种细菌种群与PFI和DI-58显著相关.
观察到特定性别的关联:酸盐生产者与女性的脆弱性较低有关,Prevotella与男性的脆弱性较低有关.
社区状态类型2具有较低的多样性和更多的病原生物,对增加的脆弱性有很高的预测能力.

结论:

肠道微生物组的改变与艾滋病毒感染者 (PWH) 的脆弱性有关.
在肠道微生物群与脆弱的关系中存在显著的基于性别的差异.
针对PWH脆弱性的有针对性的干预措施可能会从考虑性别特异性微生物组概况中受益.

关键词:

16S 16S 是一个衰老的衰老衰老的衰老艾滋病病毒艾滋病病毒艾滋病病毒炎症炎症是一种炎症.微生物组是一个微生物组.性差异的性别差异

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