睡眠模式与糖尿病视网膜病变之间的关联:从横截面和纵向证据的见解
Xixuan Zhao1,2,3,4,5, Senlin Lin2,3,4,5, Lina Lu2,3,4,5
1Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Eye (London, England)
|October 16, 2025
概括
频繁的白天小睡和过度的白天嗜睡与糖尿病视网膜病变 (DR) 的更高风险有关. 这项研究突出了影响DR流行和发病率的潜在睡眠相关因素.
科学领域:
- 眼科医生 眼科 眼科
- 睡眠医学 睡眠医学
- 遗传学 遗传学 是一个
背景情况:
- 糖尿病视网膜病变 (DR) 是导致视力丧失的主要原因.
- 了解DR的可修改风险因素对于预防和管理至关重要.
- 睡眠模式越来越被认为是各种健康结果的潜在贡献者.
研究的目的:
- 调查不同睡眠模式与糖尿病视网膜病变 (DR) 的流行率和发病率之间的联系.
- 使用孟德尔随机化探索睡眠特征和DR之间的潜在因果关系.
主要方法:
- 结合英国生物银行 (UKB) 和上海糖尿病眼病队列 (SCODE) 数据的多阶段分析.
- 使用后勤和考克斯回归模型进行横截面和纵向分析.
- 两个样本的孟德尔随机化 (MR) 与全基因组关联研究 (GWAS) 总结统计.
主要成果:
- 频繁的白天小睡与更高的DR流行率 (OR=1.847) 和发病率 (HR=2.317) 相关.
- 较长的白天睡眠时间和较高的爱普沃思睡眠度量得分也与DR患病率的增加相关.
- 门德尔的随机化表明,白天小睡和DR之间存在潜在的因果关系,尽管不完全可靠.
结论:
- 过度的白天嗜睡和频繁的白天小睡可能与糖尿病视网膜病变的风险增加有关.
- 这些发现表明,在DR风险评估和干预策略中,睡眠质量和白天嗜睡需要考虑.
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