基于MRI的多器官时钟用于健康的衰老和疾病评估
, Huizi Cao1, Zhiyuan Song1
1Laboratory of AI and Biomedical Science (LABS), Columbia University, New York, NY, USA.
Nature medicine
|October 16, 2025
概括
研究人员开发了七个基于磁共振成像的多器官生物年龄差距 (MRIBAGs),以评估器官之间的衰老. 这些MRIBAG与遗传变异,蛋白质和代谢物联系在一起,为衰老和疾病风险提供了洞察力.
科学领域:
- 生物医学工程 生物医学工程
- 遗传学 是一个遗传学.
- 老年学是指老年学的学科.
背景情况:
- 生物衰老时钟对于理解衰老和疾病至关重要.
- 现有的框架往往侧重于单个器官或组织.
- 需要全面的,多器官的衰老评估工具.
研究的目的:
- 开发和验证七个基于磁共振成像的多器官生物年龄差距 (MRIBAGs).
- 调查这些MRIBAG的遗传和分子基础.
- 探索MRIBAG与疾病风险,死亡率和认知衰退的关联.
主要方法:
- 利用了来自MULTI联盟的313,645个人的数据.
- 使用磁共振成像数据开发了七个MRIBAG.
- 进行了全基因组关联研究,遗传相关性,门德尔随机化和多omics分析.
主要成果:
- 确定了53个MRIBAG-locus对,并支持器官特异性和跨器官相互连接.
- 将MRIBAG与2,923个血蛋白,327个代谢物和24个非MRI衰老时钟联系起来.
- 针对抗衰老干预措施优先考虑了9个可用药物的基因,并将MRIBAG与疾病风险和死亡率联系起来.
结论:
- 七个MRIBAG提供了一个增强的多器官生物衰老框架.
- MRIBAGs显示了促进衰老研究和确定治疗点的临床潜力.
- 大脑MRIBAG概况与差异性认知衰退轨迹相关.
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