在人类肠道中区分饮食和微生物衍生的代谢物
Ceylan Tanes1, Weiming Hu1, Elliot Friedman2
1Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Microbiome
|October 17, 2025
概括
这项研究绘制了来自饮食和宿主的人类肠道微生物群代谢物的地图,揭示了超过2800种微生物产物及其在抗生素破坏后的恢复. 这些发现突出了肠道.
科学领域:
- 微生物组研究的研究.
- 代谢学 代谢学 代谢学
- 人类生理学 人类生理学
背景情况:
- 人的肠道微生物代谢饮食和宿主化合物,影响健康.
- 一项对成年人进行的受控养实验使用了食肉动物和肠道营养饮食.
研究的目的:
- 创建人类肠道中饮食和微生物组衍生代谢物的地图.
- 了解微生物组破坏和恢复后的代谢物变化.
主要方法:
- 使用抗生素和聚乙烯糖醇测量了微生物群枯竭前后的代谢物度.
- 与饮食组进行比较,以确定饮食衍生代谢物.
- 在抗生素治疗后评估了代谢物恢复率.
主要成果:
- 确定了2856种微生物产品和1057种微生物基质.
- 鉴定了2496种来自饮食的代谢物.
- 在全食群中,98%的肠道代谢物在7天内恢复.
- 只有93种微生物组衍生代谢物在血样本中显示出变化.
结论:
- 建立了人类肠道微生物群代谢物的地图,详细介绍了其代谢潜力.
- 量化了肠道微生物组破坏后代谢物恢复的速度.
- 确定了与炎症性肠病和肠道失调相关的代谢物.
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