透皮药物输送系统由人工智能提供动力
Farzaneh Sabbagh1, Anna Zakrzewska1, Daniel Rybak1
1Department of Biosystems and Soft Matter, Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw, 02-106, Poland.
Advanced healthcare materials
|October 17, 2025
概括
人工智能 (AI) 通过增强药物配方,预测释放,并实现个性化治疗来彻底改变皮肤间药物递送系统 (TDDS). 人工智能集成提高了对高效,以患者为中心的疗法的准确性和可扩展性.
科学领域:
- 制药科学 制药科学
- 生物医学工程 生物医学工程
- 计算生物学 计算生物学
背景情况:
- 透皮药物递送系统 (TDDS) 提供了非侵入性的治疗选择,但遇到重大发展障碍.
- 优化TDDS配方的传统方法通常耗时且昂贵,涉及广泛的临床试验.
研究的目的:
- 探索人工智能 (AI) 包括机器学习 (ML) 对TDDS发展的变革性影响.
- 突出AI在克服跨皮疗法开发和应用中的现有挑战的能力.
主要方法:
- 使用机器学习 (ML) 模型准确预测药物捕获,释放动力学,皮肤透和配方稳定性.
- 利用人工智能对新药候选药物和透增强剂进行虚拟查.
- 应用人工智能优化微针系统设计,包括几何,材料和药物加载.
- 整合人工智能驱动的生物传感器,实时进行生理监测和适应剂量.
主要成果:
- 机器学习模型在预测药物陷方面达到93.0%的准确性,显著简化了开发.
- 人工智能增强了药物释放,皮肤透和稳定性等关键参数的预测,减少了对广泛试验的需求.
- 人工智能有助于识别新的治疗剂和增强剂,加速TDDS的创新.
- 微针系统的AI驱动优化导致更高的精度和个性化的治疗交付.
结论:
- 对于复杂的TDDS数据集,人工智能比传统的建模方法提供了更高的准确性和可扩展性.
- 人工智能与先进制造 (如3D打印) 和智能材料的整合有望提供高度个性化和高效的透皮疗法.
- 在TDDS中,人工智能是促进治疗效率和以患者为中心的护理的关键,为下一代交付系统铺平了道路.
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