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Md Faysal¹, Mehrukh Zehravi², Md Al Amin¹

¹Department of Pharmacy, Faculty of Health and Life Sciences, Daffodil International University, Dhaka, 1207, Bangladesh.

Current pharmaceutical design

|October 17, 2025

概括

天然化合物在治疗三阴性乳腺癌 (TNBC) 中表现有前途,通过向关键途径和克服耐药性. 需要进一步的研究来解决有效的TNBC疗法的生物可用性和临床验证.

科学领域:

在瘤学瘤学.
药理学药理学是指药理学的学科.
自然产品化学化学

背景情况:

三阴性乳腺癌 (TNBC) 缺乏具体的点和有效的治疗方法,这给临床带来了重大挑战.
TNBC的特点是缺少雌激素受体 (ER),孕激素受体 (PR) 和HER2表达,导致攻击性行为和不良预后.

研究的目的:

审查天然化合物对TNBC的治疗潜力.
研究自然化合物向TNBC中的瘤性途径的机制.

主要方法:

使用主要的科学数据库 (PubMed,Scopus,Web of Science) 进行了全面的文献搜索.
确定和分析了评估天然化合物的抗TNBC特性及其作用机制的研究.

主要成果:

几种天然化合物 (黄素,白醇,奎尔素,EGCG,柏柏林,提摩) 在TNBC模型中表现出抗癌作用.
这些化合物抑制了扩散,转移和化学抵抗,并通过调节PI3K/AKT/mTOR,MAPK/ERK,NF-κB,JAK/STAT和Wnt/β-catenin等途径来诱导亡.
当与PARP抑制剂结合时,天然化合物可能会增强BRCA突变TNBC中的免疫疗法,通过影响PD-L1.1.等免疫检查点.

结论:

天然化合物通过向关键分子通路和克服耐药性,为TNBC治疗提供了一个有前途的补充方法.
包括不良的药理动力学,有限的生物可用性和不充分的临床验证在内的挑战需要进一步调查.
未来的研究应该优先考虑组合疗法,纳米输送系统和生物标志物驱动的临床试验,以开发有效的TNBC治疗方法.

关键词:

三阴性乳腺癌是三阴性乳腺癌.临床研究.信号通道的信号通道.治疗策略治疗策略

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