对研究化学物质及其对人类健康的影响的模型和挑战
Jana Jass1, Y Bezabhe1, Majid Mustafa2,3
1The Life Science Center, School of Science and Technology, S-701 82 Örebro University, Sweden.
Disease models & mechanisms
|October 17, 2025
概括
和多醇基物质 (PFAS) 或"永久化学品"在环境和生物中存在,对人类和生态系统健康构成风险. 本综述考察了PFAS的影响,研究它们的模型系统,以及清除策略.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 生态毒理学 生态毒理学
背景情况:
- 被称为"永恒化学品"的Per-和多基基物质 (PFAS) 在消费品中广泛使用,并且由于其半衰期长,因此持续存在.
- PFAS在环境和生物中积累,导致有毒效应,并对人类和生态系统健康产生重大关注.
- 它们无处不在的存在需要全面了解它们的环境命运和生物影响.
研究的目的:
- 为了提供Per-和多基基物质 (PFAS) 的概述.
- 讨论PFAS对人类健康和野生动物的潜在不良影响.
- 评估各种PFAS研究模型系统,并探索环境修复策略.
主要方法:
- 对Per和多基基物质 (PFAS) 的现有文献的审查.
- 在PFAS毒性研究中使用的脊椎动物和无脊椎动物模型系统的数据分析.
- 探索用于从环境中去除PFAS的现有和新兴技术.
主要成果:
- 和多醇基物质 (PFAS) 呈现持久性和生物积累,对各种生物途径产生已知的有毒作用.
- 模型系统,包括动物模型,在阐明PFAS毒性的机制方面发挥了重要作用.
- 目前正在研究一系列减轻PFAS污染的方法,但仍然存在挑战.
结论:
- 由于其持久性和毒性,和多基基物质 (PFAS) 构成了重大环境和健康挑战.
- 通过各种模型系统了解PFAS的影响对于风险评估和管理至关重要.
- 制定有效的PFAS整治策略对于保护环境和人类健康至关重要.
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