使用粘粘性纳米药物聚合物的合物进行针对性呼吸道病毒感染治疗:综合性综述
Bontha Venkata Subrahmanya Lokesh1, Rajesh Sreedharan Nair2, Najihah Binti Mohd Hashim1
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Malaya, Kuala Lumpur, Malaysia.
聚合物纳米颗粒为吸入抗病毒疗法提供了一种有前途的方法,增强了对COVID-19等呼吸道感染的肺部药物输送. 这一策略旨在提高治疗效果,减少副作用.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 呼吸系统医学 呼吸系统医学
背景情况:
- 肺部药物输送对呼吸道感染是有效的,提供有针对性的作用和减少全身毒性.
- 吸入疗法绕过第一通代谢,用于局部治疗COVID-19和流感等病毒感染.
- 聚合物纳米颗粒显示出提高药物的生物可用性和向性在肺部治疗中的潜力.
研究的目的:
- 审查基于气溶的抗病毒纳米药物输送系统,使用天然和可生物降解的聚合物.
- 探索用于呼吸道病毒感染的聚合物纳米颗粒的设计,结合和应用.
- 讨论克服可吸入纳米药物输送方面的挑战的战略.
主要方法:
- 关于用于肺部药物输送的聚合物纳米粒子的文献综述.
- 分析粘粘性质和聚合物-药物结合,以增强药物保留.
- 对可生物降解和pH响应的聚合物进行讨论,以控制释放.
主要成果:
- 粘膜粘合和聚合物-药物结合通过与呼吸道粘膜的相互作用来改善药物保留.
- 可生物降解,pH响应的聚合物有助于控制和向的药物释放.
- 现有战略可以应对气溶化,设备设计和粒子特性方面的挑战.
结论:
- 吸入的聚合物纳米药物合物具有治疗呼吸道病毒感染的巨大潜力.
- 这种方法可以减少病毒载荷,限制传播,并最大限度地减少系统性副作用.
- 未来的发展重点是可扩展,自主管理的系统,以广泛使用.
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