为性别转变接受激素治疗的个体的头痛:一个横截面的观察性研究
Lucia Jimena Zavala1, Andreina Gil Ramirez2, Kjersti Grøtta Vetvik3,4
1Danish Headache Center, Department of Neurology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
Headache
|October 17, 2025
概括
性别确认激素治疗 (GAHT) 影响跨性别者的头痛频率. 基于雌激素的GAHT与头痛增加有关,而基于的GAHT可能会改善头痛症状.
科学领域:
- 神经学 神经学
- 内分泌学 在内分泌学.
- 跨性别者健康 跨性别者健康
背景情况:
- 偏头痛不成比例地影响着性别女性,荷尔蒙波动起着关键作用.
- 关于经历GAHT的跨性别和非二进制个体的头痛患病率和特征存在重大知识差距.
- 了解这些模式对于全面的跨性别医疗保健至关重要.
研究的目的:
- 为了确定发病率,频率和特征的头痛障碍在跨性别个人在GAHT.
- 调查GAHT和头痛病理生理学的关系,特别是偏头痛.
- 测试基于雌激素的GAHT增加头痛风险,而基于的GAHT减少头痛风险的假设.
主要方法:
- 采用匿名在线调查进行的横截面观察性研究.
- 在阿根廷接受GAHT的18岁以上的跨性别和非二进制个体.
- 采用了偏头痛屏幕问卷 (MS-Q) 并评估了与GAHT相关的头痛变化.
主要成果:
- 160名参与者中有63.7%的人报告了头痛;86.3%的人服用丸激素,11.8%的人服用雌激素.
- 只有24.5%的患者有先前的头痛诊断,但46.1%的患者通过MS-Q.检测出偏头痛类头痛的阳性.
- 雌激素使用者报告新发/恶化的头痛的频率高于 (66.6%) 的丸激素使用者 (27.2%);丸激素使用者报告改善的频率高于 (26.1%) 的雌激素使用者 (8.3%).
结论:
- 基于雌激素的GAHT与新发或恶化的头痛的发病率较高有关.
- 基于的GAHT更频繁地与头痛改善或解决有关.
- 这些发现强调了需要进一步研究GAHT对头痛模式的影响,以及这一群体中低诊断的头痛障碍的高率.
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