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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
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激活内源性带状干细胞以增强TMJ修复

T Tuwatnawanit1,2, N Anthwal1, A S Tucker1

  • 1Centre for Craniofacial and Regenerative Biology, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London, London, UK.

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概括

关节疾病 (TMDs) 的再生疗法正在通过向纤维软骨干/原生细胞 (FCSCs) 取得进展. 通过信号通路刺激这些细胞可以增强动物模型中关节的修复.

关键词:
纤维软骨纤维的使用骨关节炎是一种关节炎.复兴再生是一种再生方式.信号通道的信号路径.干细胞的利基是干细胞.部关节疾病 部关节疾病

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科学领域:

  • 生物医学工程 生物医学工程
  • 再生医学是一种再生医学.
  • 干细胞生物学 干细胞生物学

背景情况:

  • 关节疾病 (TMD) 严重影响生活质量,因为关节的自我修复能力有限.
  • 软骨纤维干细胞/原始细胞 (FCSCs) 在体中是TMJ再生的关键目标.
  • 信号通路 (Wnt, Hedgehog, Notch) 调节FCSC行为和肌关节的发育.

研究的目的:

  • 通过针对FCSC来探索TMJ疾病的再生策略.
  • 研究TMJ再生中信号通路的作用.
  • 开发用于关节修复的新型治疗方法.

主要方法:

  • 在动物模型中追踪状FCSCs的体内血统.
  • 操纵关键信号通路 (Wnt,刺,) 以刺激内源干细胞.
  • 信号通路调制与生物工程技术的结合,包括脚手架的开发.

主要成果:

  • 在关节尾中识别FCSC亚群和支细胞.
  • 在各种动物模型 (老鼠,老鼠,子,猪) 中通过通路刺激来证明增强关节再生能力.
  • 生物工程支架的成功整合,以控制路径调节器的传递.

结论:

  • 准TMJ FCSC及其相关信号通路为再生疗法提供了一个有希望的途径.
  • 先进的生物工程与途径操纵相结合,可以促进关节结构的真正再生.
  • 基于水凝的注射疗法正在成为TMJ修复和症状缓解的新方法.