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激活内源性带状干细胞以增强TMJ修复

T Tuwatnawanit^1,2, N Anthwal¹, A S Tucker¹

¹Centre for Craniofacial and Regenerative Biology, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London, London, UK.

Journal of dental research

|October 17, 2025

概括

关节疾病 (TMDs) 的再生疗法正在通过向纤维软骨干/原生细胞 (FCSCs) 取得进展. 通过信号通路刺激这些细胞可以增强动物模型中关节的修复.

科学领域:

生物医学工程生物医学工程
再生医学是一种再生医学.
干细胞生物学干细胞生物学

背景情况:

关节疾病 (TMD) 严重影响生活质量,因为关节的自我修复能力有限.
软骨纤维干细胞/原始细胞 (FCSCs) 在体中是TMJ再生的关键目标.
信号通路 (Wnt, Hedgehog, Notch) 调节FCSC行为和肌关节的发育.

研究的目的:

通过针对FCSC来探索TMJ疾病的再生策略.
研究TMJ再生中信号通路的作用.
开发用于关节修复的新型治疗方法.

主要方法:

在动物模型中追踪状FCSCs的体内血统.
操纵关键信号通路 (Wnt,刺,) 以刺激内源干细胞.
信号通路调制与生物工程技术的结合,包括脚手架的开发.

主要成果:

在关节尾中识别FCSC亚群和支细胞.
在各种动物模型 (老鼠,老鼠,子,猪) 中通过通路刺激来证明增强关节再生能力.
生物工程支架的成功整合,以控制路径调节器的传递.

结论:

准TMJ FCSC及其相关信号通路为再生疗法提供了一个有希望的途径.
先进的生物工程与途径操纵相结合,可以促进关节结构的真正再生.
基于水凝的注射疗法正在成为TMJ修复和症状缓解的新方法.

关键词:

纤维软骨纤维的使用骨关节炎是一种关节炎.复兴再生是一种再生方式.信号通道的信号路径.干细胞的利基是干细胞.部关节疾病部关节疾病

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