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微型/纳米机器人对抗大脑疾病:挑战,进展和前景

Qi Zhang^1,2, Dong Sun¹

¹Department of Biomedical Engineering, City University of Hong Kong, Hong Kong SAR, 999077, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|October 17, 2025

概括

微型/纳米机器人 (MNRs) 为脑部疾病提供精确的药物输送,克服治疗障碍. 这些先进的机器人系统显示了未来神经治疗的变革潜力.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
神经科学是一个神经科学.

背景情况:

脑部疾病是全球主要的健康挑战.
目前的治疗方法面临的局限性包括药物透率低下和中枢神经系统障碍.
迫切需要创新的治疗策略.

研究的目的:

审查治疗大脑疾病的挑战.
突出微/纳米机器人 (MNRs) 作为一种新的治疗平台.
讨论MNR在克服交付障碍方面的作用.

主要方法:

对脑部疾病的MNR现有文献进行系统审查.
分析MNR推进原理 (自动推进和外部启动).
检查MNR应用中的图像指导和实时跟踪.

主要成果:

最多的NRs能够高精度地提供有针对性的交付,解决常规治疗的局限性.
详细介绍了各种推进方法 (化学,生物混合,声学,光学,电气,磁性).
图像指导和跟踪对于MNRs的临床翻译至关重要.

结论:

经过多次检测,MNR显示出对彻底改变大脑疾病治疗的巨大潜力.
进一步开发和临床转化对于实现其全部潜力至关重要.
先进的MNR技术可以重塑神经疾病的治疗范式.

关键词:

血脑屏障血脑屏障血脑屏障血脑屏障脑部疾病脑部疾病药物输送是药物输送的过程.微型 / 纳米机器人

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