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Xiao-Xuan Tang¹, Rui Wu¹, Jun-Hui Chen¹

¹Department of Gastroenterology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.

Metabolism open

|October 17, 2025

概括

胰岛素耐药性高平静模型评估 (HOMA-IR) 显著增加了MASH风险. 监测HOMA-IR有助于早期检测和干预与代谢功能障碍相关的脂肪性肝病 (MASLD).

科学领域:

肝病学肝病学是一种肝病学.
代谢综合征是代谢综合征的一种.
内分泌学在内分泌学.

背景情况:

与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的健康问题.
MASH代表了MASLD的一个关键,更先进的阶段.
通过HOMA-IR表示的胰岛素耐药性是MASLD进展的关键因素.

研究的目的:

调查胰岛素耐药性同居模式评估 (HOMA-IR) 与MASH风险之间的关联.
评估HOMA-IR与肝硬度 (LSM) 和脂肪含量 (CAP) 的关系.
探索BMI在这些关联中的调解作用.

主要方法:

来自NHANES 2017-2020年数据的700名成年人的分析.
使用MASH风险分层的FAST得分.
采用了逻辑和线性回归,受限立方线 (RCS) 和因果调解分析.

主要成果:

在最高的HOMA-IR四分位数中的个体具有显著更高的MASH风险 (OR=5.942).
在HOMA-IR和MASH风险,LSM和CAP之间发现了非线性关联.
HOMA-IR与增加的肝硬化和纤维化相关;BMI调解了这些影响.

结论:

HOMA-IR是早期MASH风险识别的关键标记.
针对胰岛素抵抗和BMI的干预措施可以减轻MASH的风险和严重程度.
综合治疗策略对于管理MASLD和MASH至关重要.

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