心肺移植的特定风险因素
Justin Issard1,2, Jérôme Le Pavec3, Gaelle Dauriat3
1Inserm UMR_S 999 (Pulmonary Arterial Hypertension: Pathophysiology and Therapeutic Innovations), Paris-Saclay University, Le Plessis-Robinson, France.
JHLT open
|October 17, 2025
概括
心肺移植 (HLTx) 很少见,但对于复杂的心肺疾病至关重要,特别是与先天性心脏病 (CHD) 相结合的艾森门格综合征 (ES). 专家中心显示,生存率有所改善,在1年后超过85%.
科学领域:
- 心脏病学 心脏病学
- 胸部外科手术 胸部外科手术
- 移植医学 移植医学
背景情况:
- 心肺移植 (HLTx) 越来越罕见,全球每年不到50次手术.
- 在先天性心脏病 (CHD) 中,艾森门格综合征 (ES) 主导着不断变化的指示.
- HLTx是复杂的,具有显著的术后和长期风险,特别是在ES/CHD患者中.
研究的目的:
- 在现代指示中识别HLTx风险因素.
- 检查患者的选择,列表时间,外科手术期间的挑战和结果.
- 专注于ES和CHD相关的HLTx病例.
主要方法:
- 综合了当前的文献.
- 分析了注册表数据.
- 专注于ES和CHD患者群体.
主要成果:
- HLTx候选人出现并发症,如先前的手术,多细胞血症和多器官功能障碍,增加复杂性.
- 长时间的等待列表和供体短缺使管理复杂化.
- 专家中心报告说,1年生存率>85%的改善以及对移植功能障碍的潜在保护作用.
结论:
- HLTx是选择选择复杂心肺疾病的治疗方法,特别是带有心肺病的ES.
- 优化结果需要早期推,风险分层和专家中心管理.
- 进步提高了生存率,但HLTx需要多学科的专业知识和个性化的护理.
相关概念视频
Kidney Transplant I: Introduction
339
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
339
Pulmonary Tuberculosis I
822
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
822
Heart Failure I: Introduction
678
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
678
Tissue Transplantation
894
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
894
Factors Affecting Pulmonary Ventilation
2.8K
Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
2.8K
Other Pulmonary Disorders
1.5K
Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
1.5K


