Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Regulation of the Unfolded Protein Response01:31

Regulation of the Unfolded Protein Response

2.9K
Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
2.9K
Other Stress Responses in Bacteria01:30

Other Stress Responses in Bacteria

335
Bacteria have global regulatory systems that control several types of stress mechanisms. These include Pho regulon and the heat shock response, which are essential systems for environmental adaptation, such as nutrient limitation and proteotoxic stress. The Pho regulon and the heat shock response exemplify bacterial resilience, enabling rapid adaptation to fluctuating environmental conditions.Pho RegulonBacteria require phosphorus for essential cellular processes, including nucleic acid...
335
RNA Stability01:53

RNA Stability

35.6K
Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
35.6K
Stringent Response in E. coli01:23

Stringent Response in E. coli

292
Bacterial growth is closely tied to nutrient availability, with cells proliferating exponentially under favorable conditions and entering a stationary phase when resources become scarce. This transition is mediated by a regulatory mechanism known as the stringent response, which allows bacteria to adapt to nutrient deprivation by modulating gene expression and metabolic activity.During nutrient scarcity, intracellular amino acid levels decline. It results in the accumulation of uncharged tRNAs...
292
Riboswitches01:56

Riboswitches

9.5K
Riboswitches are non-coding mRNA domains that regulate the transcription and translation of downstream genes without the help of proteins. Riboswitches bind directly to a metabolite and can form unique stem-loop or hairpin structures in response to the amount of the metabolite present. They have two distinct regions – a metabolite-binding aptamer and an expression platform.
The aptamer has high specificity for a particular metabolite which allows riboswitches to specifically regulate...
9.5K
Stress Response System01:21

Stress Response System

651
The stress response system, also known as the fight-or-flight response, is the body's automatic physiological reaction to perceived threats. Hans Selye introduced the concept of General Adaptation Syndrome (GAS) to describe the predictable pattern of changes that occur in response to stress. GAS consists of three sequential stages: alarm, resistance, and exhaustion. This model helps explain how chronic stress can contribute to health problems.
Alarm stage
In the alarm stage, the body's...
651

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Translation control of autophagy genes modulates cellular response to hydroxyurea-induced genotoxic stress.

Autophagy·2026
Same author

RGG-motif protein Scd6 affects oxidative stress response by regulating cytosolic caTalase T1 (Ctt1).

RNA biology·2026
Same author

Author Correction: Genotoxic stress triggers Scd6-dependent regulation of translation to modulate the DNA damage response.

EMBO reports·2025
Same author

Genotoxic stress triggers Scd6-dependent regulation of translation to modulate the DNA damage response.

EMBO reports·2025
Same author

Instantaneous formation of interstellar minerals and mineral quantum dots.

RSC advances·2025
Same author

Tdh3 and Rom2 are functional modulators of a conserved condensate-resident RNA-binding protein, Scd6, in Saccharomyces cerevisiae.

Genetics·2024

相关实验视频

Updated: Jan 14, 2026

Monitoring Protein-RNA Interaction Dynamics In Vivo at High Temporal Resolution Using χCRAC
09:15

Monitoring Protein-RNA Interaction Dynamics In Vivo at High Temporal Resolution Using χCRAC

Published on: May 9, 2020

5.6K

рибо核蛋白 (RNP) 凝聚剂在应对火星类压力条件时调节生存率.

Riya Dhage1, Arijit Roy2, Bhalamurugan Sivaraman2

  • 1Department of Biochemistry, Indian Institute of Science, Bangalore 560012, India.

PNAS nexus
|October 17, 2025
PubMed
概括

酵母通过形成核糖蛋白 (RNP) 凝聚物,特别是P体,在强烈的冲击波和酸盐压力中存活下来. 这一发现提供了对生命的洞察力.

关键词:
火星 火星 火星 火星 火星超酸盐应激反应的压力核糖核蛋白 (RNP) 凝缩物冲击波,冲击波,冲击波是什么

更多相关视频

Measurements of Physiological Stress Responses in C. Elegans
10:36

Measurements of Physiological Stress Responses in C. Elegans

Published on: May 21, 2020

14.8K
Molecular Modulation by Lentivirus-Delivered Specific shRNAs in Endoplasmic Reticulum Stressed Neurons
10:50

Molecular Modulation by Lentivirus-Delivered Specific shRNAs in Endoplasmic Reticulum Stressed Neurons

Published on: April 24, 2021

1.3K

相关实验视频

Last Updated: Jan 14, 2026

Monitoring Protein-RNA Interaction Dynamics In Vivo at High Temporal Resolution Using χCRAC
09:15

Monitoring Protein-RNA Interaction Dynamics In Vivo at High Temporal Resolution Using χCRAC

Published on: May 9, 2020

5.6K
Measurements of Physiological Stress Responses in C. Elegans
10:36

Measurements of Physiological Stress Responses in C. Elegans

Published on: May 21, 2020

14.8K
Molecular Modulation by Lentivirus-Delivered Specific shRNAs in Endoplasmic Reticulum Stressed Neurons
10:50

Molecular Modulation by Lentivirus-Delivered Specific shRNAs in Endoplasmic Reticulum Stressed Neurons

Published on: April 24, 2021

1.3K

科学领域:

  • 天体生物学和天体生物学.
  • 细胞生物学和应激反应
  • 生物化学和分子生物学

背景情况:

  • 探索火星上的生命需要了解适应辐射,冲击波和酸盐等极端条件的适应.
  • 生物利用核糖蛋白 (RNP) 凝结物作为一种保护机制,以适应环境压力因素.
  • 已知P体是参与RNA调节的已知压力诱导的RNP凝聚物.

研究的目的:

  • 在模拟的火星压力条件下 (冲击波和酸盐) 调查酵母的生存能力和适应机制.
  • 阐明RNP凝聚物,特别是P体在酵母对这些压力因素的反应中的作用.
  • 为了确定参与火星应激适应的分子参与者.

主要方法:

  • 将酵母暴露在高强度冲击波 (5.6M) 和甲中.
  • 显微镜观察P体的形成并评估酵母菌的生长.
  • 转录组分析以确定在压力下和P体突变者中的基因表达变化.

主要成果:

  • 酵母在5.6M冲击波下显示出生存能力.
  • 冲击波和酸盐都诱导了P体的形成.
  • 缺乏P体组装的突变体在化物应激下表现出增长受损,转录组分析显示了与RNP凝结物和火星应激相关的转录变异.

结论:

  • RNP凝结物,特别是P体,在酵母适应火星环境压力因素方面发挥着至关重要的作用.
  • 这项研究确立了火星应激反应和RNP凝结体动力学之间的新联系.
  • 在太空探索期间,RNP凝结物显示出作为评估生命健康状况的生物标志物的潜力.