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补充剂用于术后预防喉疼痛:来自系统审查和元分析的证据
Sumit Bansal1, Siddhartha Dutta2, Rima B Shah2
1Department of Anesthesia, AIIMS, Rajkot, Gujarat, India.
Journal of dental anesthesia and pain medicine
|October 17, 2025
概括
补充剂显著降低了术后喉疼痛 (POST) 的整体发病率. 这种预防性治疗在减轻轻度POST症状方面最有效.
科学领域:
- 麻醉学和外科手术期间的医学.
- 药理学和治疗学 药理学和治疗学
- 营养科学 营养科学
背景情况:
- 手术后喉痛 (POST) 是气管管道输液后的常见并发症,对患者的体验产生负面影响.
- 气道刺激和炎症是POST的主要原因.
- 具有抗炎和伤口愈合的特性,使其成为POST的潜在治疗剂.
研究的目的:
- 系统地审查和元分析在预防和治疗术后喉疼痛方面的疗效.
- 评估对POST的整体发病率和严重程度的影响.
主要方法:
- 在PubMed,Cochrane控制试验中央注册表和Clinicaltrials.gov.gov进行了全面的文献搜索.
- 确定了6项临床试验,其中3项被纳入了元分析,所有6项都被纳入了系统性审查.
- 数据综合和偏差风险评估使用Cochrane审查管理器v.5.4.1和Cochrane偏差风险2.0工具进行.
主要成果:
- 与安慰剂相比,显著降低了POST的整体发病率 (OR = 0.29,P < 0.0001).
- 在组中,轻度POST的发生率在输出管后0,2小时和4小时显著降低.
- 两组之间在中度和重度POST的严重程度上没有发现显著差异.
结论:
- 补充剂是一种有效的策略,可以减少术后喉疼痛的总体发病率.
- 具有显著的预防作用,特别是在轻微的POST病例中.
- 对中度至重度POST的最佳剂量和管理进行进一步的研究可能是有必要的.
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