内脏脂肪代谢得分与白内素尿风险之间的J形关联:基于人口的研究
Yuren Zhang1, Jinting Xu1, Yiping Zhang1
1Department of Endocrinology & Metabolism, Jinjiang Municipal Hospital, Shanghai Sixth People's Hospital Fujian, Quanzhou, Fujian, China.
Frontiers in endocrinology
|October 17, 2025
概括
对内脏脂肪的代谢评分 (METS-VF) 与美国成年人患白蛋白尿的风险更高有关. 增加的METS-VF水平与更高的白蛋白尿的患病率相关,突出显示内脏脂肪.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學.
- 代谢健康 代谢健康
背景情况:
- 内脏脂肪积累是心脏代谢风险的一个关键因素.
- 白蛋白尿是损伤和心血管疾病的早期标志物.
- 内脏脂肪代谢评分 (METS-VF) 是评估内脏脂肪的新型指标.
研究的目的:
- 评估内脏脂肪代谢评分 (METS-VF) 与美国成年人中白蛋白尿的患病率之间的关联.
- 探索内脏脂肪评估和损伤指标之间的关系.
主要方法:
- 使用国家健康和营养检查调查 (NHANES) 数据 (1999-2018) 的横截面研究.
- 包括22514名20岁及以上的美国成年人.
- 使用METS-IR计算的METS-VF,腰与身高的比例,年龄和性别;白色素尿定义为UACR≥30 mg/g.
主要成果:
- 与非白尿症组相比,在白尿症组中观察到较高的METS-VF水平.
- 随着METS-VF水平的上升,Albuminuria患病率逐渐增加.
- METS-VF显示与白尿风险有显著的关联 (OR = 1.406);确定了一个J形的剂量反应关系,值为6.128.
结论:
- METS-VF可以作为一种有价值的流行病学工具,以了解内脏脂肪对白蛋白尿风险的贡献.
- 这些发现表明,内脏脂肪和功能障碍之间存在联系.
- 需要进一步的大规模前性研究来证实这些关联.
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