预防 fentanyl 诱导的咳的 ketorolac:一个前性,随机和双盲研究
Nasrin Nouri1, Alireza Pournajafian1, Sara Tahzibi2
1Department of Anesthesiology, Firoozgar Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Anesthesiology and pain medicine
|October 17, 2025
概括
凯托洛拉克有效地减少了芬太尼诱导的咳严重程度,在利多卡因禁用时提供了替代方案. 这项研究在凯托洛拉克组中没有发现任何严重的咳病例,这突显了其安全性和有效性.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 芬太尼是一种常见的麻醉剂,可以触发反射咳.
- 在麻醉期间咳可能会导致并发症.
- 利多卡因通常用于减轻芬太尼诱导的咳,但有禁忌.
研究的目的:
- 评估Ketorolac在减少芬太尼引起的咳方面的有效性.
- 为了比较托拉克与利多卡因和安慰剂对咳的抑制.
- 确定利多卡因的安全替代品,以预防芬太尼引起的咳.
主要方法:
- 210名患者的前性随机对照试验 (ASA I/II).
- 三组在注射芬太尼之前接受了凯托洛拉克,利多卡因或正常盐水.
- 咳的发作和严重程度在芬太尼尔给药后的三分钟内被评估.
主要成果:
- 在各组之间观察到咳发作和严重性的显著差异 (P=0.001).
- 与盐水相比,托拉克和利多卡因显著降低了咳的频率和强度.
- 凯托洛拉克组中没有出现严重的咳;注射后的血压在各组之间有显著的差异.
结论:
- 凯托洛拉克有效降低了芬太尼引起的咳的发生率和严重程度.
- 凯托洛拉克可以作为利多卡因的可行替代品,当后者违禁时.
- 在麻醉前服用凯托洛拉克可以通过预防严重的咳发作来提高患者的安全性.
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