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老年人肉症和骨质疏松症之间的相关性:系统性审查和元分析
Sha Jin1, Fengming Zheng1, Huaili Liu1
1Department of Geriatrics, Hangzhou Third People's Hospital, Hangzhou, China.
Frontiers in medicine
|October 17, 2025
概括
皮症显著增加了老年人骨质疏松症的风险. 这种关联因性别而异,男性的风险较高,在欧洲人群中最为强烈.
科学领域:
- 老年学是一门学科.
- 肌肉骨健康 肌肉骨健康
- 流行病学 流行病学
背景情况:
- 肉症和骨质疏松症是常见的老年综合征,增加了跌倒,骨折和残疾的风险.
- 共同的机制包括荷尔蒙变化,炎症和减少机械负荷.
- 缺乏关于沙尔科佩尼亚和骨质疏松症之间的流行病学联系和相互作用的共识,特别是在不同的人群中.
研究的目的:
- 量化评估全球老年人肉类和骨质疏松症之间的关联.
- 分析地理位置,性别,人口特征和诊断标准如何调节这种关联.
主要方法:
- 14项观察性研究的系统综述和元分析 (n=182,307).
- 在PubMed,Embase,Cochrane图书馆和CNKI数据库中进行了搜索.
- 使用纽卡斯尔-太华尺度评估研究质量;使用Review Manager 5.4和Stata 17.0.0进行的元分析.
主要成果:
- 皮症显著增加骨质疏松症的风险 (OR=3.16).
- 与女性 (OR=3.46) 相比,患有肉症的男性患骨质疏松症的风险更高 (OR=4.74).
- 欧洲人群的风险最高 (OR=4.37),其次是亚洲人群 (OR=2.66) 和美国人群 (OR=2.32). 居住在社区的人更容易受到感染 (OR=3.70).
结论:
- 肉类是骨质疏松症的重要风险因素,全球风险概况各不相同.
- 这种关联在男性和欧洲人群中更为强烈.
- 由于方法上的局限性,需要进行进一步的大规模前性研究来验证这些发现.
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