储存时间对FFP凝血因子活性的影响
Frontiers in medicine
|October 17, 2025
概括
在储存期间,新鲜冷血 (FFP) 保持正常的凝血功能 (PT,APTT). 然而,随着时间的推移,第八因子 (FVIII) 的活性显著下降,需要对近300天存储的FPF进行增强的库存管理.
科学领域:
- 输血医学 输血医学
- 血液学 血液学 血液学
- 临床病理学 临床病理学
背景情况:
- 新鲜冷血 (FFP) 是一种用于治疗凝血因子缺乏症的关键血液产品.
- 在标准储存期间了解FPF中的凝血因子的稳定性对于有效的临床使用和库存管理至关重要.
研究的目的:
- 在标准条件下 (≤-18°C) 在一年的储存期内研究FPF的凝结因子活性变化.
- 评估FPF在其整个保质期内的质量特征.
- 提供基于数据的建议,以优化FFP库存和医疗保健机构的营业额策略.
主要方法:
- 在标准条件下 (≤-18 °C) 储存长达1年的FPF的纵向研究.
- 在不同时间点测量激活的部分血栓形成时间 (APTT),前列血时间 (PT),国际正常化比率 (INR) 和第八因子 (FVIII) 活性.
- 对收集的凝血参数进行统计分析.
主要成果:
- 输血组时间 (PT) 和激活的部分血栓形成时间 (APTT) 显示,随着储存时间的延长,增长趋势,一般保持在正常范围内.
- 在储存300天后,观察到PT生长率的显著增加.
- 第八因子 (FVIII) 活性比基线下降了19.35%,只有72%的样本在储存120天后合格.
结论:
- 虽然PT和APTT保持在正常范围内,但FFP经历了某些凝血因子活动的显著下降,特别是FVIII,随着长时间的储存.
- 应加强库存管理策略,以确保FFP接近300天的存储时间,以确保产品的有效性.
- 这些发现支持需要仔细监测FFP质量和及时利用,以最大限度地提高治疗效益.
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