微生物组介导化学或放射治疗反应的调节
Lan Zhou1, Benhua Li2, Juan Ren1
1Department of Clinical Laboratory, Affiliated Hospital of Panzhihua University, Panzhihua, China.
Frontiers in oncology
|October 17, 2025
概括
肠道微生物组通过影响治疗疗效和毒性,显著影响化疗和放射治疗的结果. 调节肠道细菌显示出优化癌症治疗和减少副作用的前景.
科学领域:
- 在瘤学瘤学.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 肠道微生物群在宿主生理学中起着至关重要的作用,并影响患者对癌症治疗的反应.
- 化学辐射疗法可以破坏肠道微生物平衡,导致肠道损伤,炎症和免疫功能障碍的增加.
- 特定的肠道微生物及其代谢物可以提高治疗效率并调节宿主反应.
研究的目的:
- 审查肠道微生物群影响化疗辐射疗法的疗效和毒性的机制.
- 总结微生物失生症如何影响治疗结果和宿主免疫反应.
- 突出潜在的基于微生物组的策略,以优化化疗或放射治疗.
主要方法:
- 关于肠道微生物群和化学放射治疗的临床前和临床研究的文献综述.
- 分析关键的分子机制,包括信号通路和代谢重编程.
- 针对肠道微生物组的临床干预措施的评估.
主要成果:
- 化学放射治疗诱导的肠道功能障碍会加剧肠道损伤,全身炎症和免疫功能障碍.
- 代谢物和代谢物通过代谢重编程,DNA修复和免疫激活来增强化疗反应.
- 微生物介导的机制包括TLR/NF-κB信号传递,SCFA表观遗传修饰和免疫检查点抑制剂强化.
结论:
- 肠道微生物群是化学放射治疗精度和患者结果的关键决定因素.
- 准肠道微生物组为治疗优化和减轻与治疗相关的毒性提供了潜力.
- 微生物群引导的策略,包括益生菌和便微生物群移植,有望改善癌症治疗反应.
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